Overall focus

The laboratory focuses on the study of how brain pathologies affect the neurovascular unit and how these changes lead to the disruption of the Blood-Brain Barrier (BBB).  Overall, it is our hope that the studies pursued will lead to the discovery of therapeutic agents that are both anti-inflammatory and barrier protective in order to attenuate the deleterious outcomes of neuroinflammation and neurodegeneration.  In addition to endothelial/vascular biology, our expertise also includes neuroscience, immunology, molecular biology, microbiology, biochemistry and microfluidics.  Importantly, (in addition to in-vitro and ex-vivo methodologies) the laboratory also routinely utilizes animal models to study disease progression and for testing novel therapeutic approaches.  In particular, as it relates to drug abuse, sepsis, HIV-1 related CNS inflammation and traumatic brain injury.  Lastly, we employ a translational approach to our research by using primary human cells and relevant clinical samples (i.e., tissue, serum, CSF) to validate and further extend our findings.

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